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Imaging the Neurovascular Unit with FTIR

Feb. 14, 2024

Stroke is a large concern to the public health sector. This intricate review article advertises the use of infrared imaging conducted with the Agilent microscope at the Mid-IR beamline to identify key biomarkers of stroke within brain tissue. Researchers use FTIR imaging to analyze changes in brain tissue enabling a more holistic approach to characterizing pathophysiological responses - helping us understand the processes occuring in stroke incidence and identifying risk factors - in disease and disease models. A detailed description of machine learning with Orange/Quasar data analysis is presented to aid differentiation and characterization of tissue sections. Tissue preparation methods suitable for FTIR imaging analysis are also detailed.

Read the paper!

Boseley, R.E.; Sylvain, N.J.; Peeling, L.; Kelly, M.E.; Pushie, M.J. A review of concepts and methods for FTIR imaging of biomarker changes in the post-stroke brain. Biochim Biophys Acta Biomembr 2024, 1866 (3), 184287. https://doi.org/10.1016/j.bbamem.2024.184287